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Metabolic syndrome: definitions and controversies ?
Metabolic syndrome (MetS) is a complex disorder with high socioeconomic cost that is considered a worldwide epidemic. MetS is defined by a cluster of interconnected factors that directly increase the risk of coronary heart disease (CHD), other forms of cardiovascular atherosclerotic diseases (CVD), and diabetes mellitus type 2 (DMT2). Its main components are dyslipidemia (elevated triglycerides and apolipoprotein B (apoB)-containing lipoproteins, and low high-density lipoproteins (HDL)), elevation of arterial blood pressure (BP) and dysregulated glucose homeostasis, while abdominal obesity and/or insulin resistance (IR) have gained increasing attention as the core manifestations of the syndrome
What is metabolic syndrome?
Metabolic syndrome is a collection of heart disease risk factors that increase your chance of developing heart disease, stroke, and diabetes. The condition is also known by other names including Syndrome X, insulin resistance syndrome, and dysmetabolic syndrome. According to a national health survey, more than 1 in 5 Americans has metabolic syndrome. The number of people with metabolic syndrome increases with age, affecting more than 40% of people in their 60s and 70s.
Heart Health
Total Cholesterol
LDL Cholesterol
HDL Cholesterol
Total Cholesterol / HDL
Cholesterol Ratio
Triglycerides
Apolipoprotein B / A-I Ratio
Apolipoprotein CII
Apolipoprotein CIII
Small LDL Cholesterol
High Sensitivity C-Reactive
Protein (hsCRP)
Cardiovascular Risk Score
Heart-type Fatty Acid
Binding Protein (H-FABP) 1
Metabolic Syndrome
Height
Weight
Body Mass Index (BMI)
Waist Circumference
Systolic Blood Pressure
Diastolic Blood Pressure
Glucose *
HDL Cholesterol
Triglycerides
HbA1c
Insulin
C-peptide
Leptin
Adiponectin
Resistin
High Sensitivity C-Reactive
Protein (hsCRP)
Diabetes Health
Glucose*
HbA1c
Insulin
C-peptide
Health Tips & Info
Additionally, children’s reference ranges are designed to provide more accurate pediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes.
Since physical inactivity and excess weight are the main underlying contributors to the development of metabolic syndrome, exercising, eating healthy and, if you have overweight or obesity, working toward a weight that's healthy for you can help reduce or prevent the complications associated with this condition. Your doctor may also prescribe medications to manage some aspects of your problems associated with metabolic syndrome.
Consistently high levels of insulin and glucose are linked to many harmful changes to the body, including:
Damage to the lining of coronary and other arteries, a key step toward the development of heart disease or stroke
Changes in the kidneys' ability to remove salt, leading to high blood pressure, heart disease and stroke
An increase in triglyceride levels, resulting in an increased risk of developing cardiovascular disease
An increased risk of blood clot formation, which can block arteries and cause heart attacks and strokes
A slowing of insulin production, which can signal the start of type 2 diabetes, a disease that is in itself associated with an increased risk for a heart attack or stroke. Uncontrolled diabetes is also associated with complications of the eyes, nerves, and kidneys.
Fatty liver, which is sometimes associated with inflammation of the liver (non-alcoholic seatohepatitis, or NASH). If untreated, NASH could lead to cirrhosis and liver failure.
Damage to the lining of coronary and other arteries, a key step toward the development of heart disease or stroke
Changes in the kidneys' ability to remove salt, leading to high blood pressure, heart disease and stroke
An increase in triglyceride levels, resulting in an increased risk of developing cardiovascular disease
An increased risk of blood clot formation, which can block arteries and cause heart attacks and strokes
A slowing of insulin production, which can signal the start of type 2 diabetes, a disease that is in itself associated with an increased risk for a heart attack or stroke. Uncontrolled diabetes is also associated with complications of the eyes, nerves, and kidneys.
Fatty liver, which is sometimes associated with inflammation of the liver (non-alcoholic seatohepatitis, or NASH). If untreated, NASH could lead to cirrhosis and liver failure.
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What are the symptoms of metabolic syndrome?
Usually, there are no immediate physical symptoms. Medical problems associated with the metabolic syndrome develop over time. If you are unsure if you have metabolic syndrome, see your healthcare provider. He or she will be able to make the diagnosis by obtaining the necessary tests, including blood pressure, lipid profile (triglycerides and HDL) and blood glucose.
Syndrome X
insulin resistance syndrome
dysmetabolic syndrome
stroke
diabetes
acanthosis nigricans
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