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Genetic Coeliac Disease

When you have symptoms suggesting celiac disease, such as chronic diarrhea, bloating, abdominal pain, anemia, and weight loss; when an infant is chronically irritable or fails to grow at a normal rate; when a close family member has celiac disease; when you are being treated for celiac disease

£120
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Celiac Disease
Many people with celiac disease don't know they have it. Two blood tests can help diagnose it:
Serology testing looks for antibodies in your blood. Elevated levels of certain antibody proteins indicate an immune reaction to gluten.
Genetic testing for human leukocyte antigens (HLA-DQ2 and HLA-DQ8) can be used to rule out celiac disease.
It's important to be tested for celiac disease before trying a gluten-free diet. Eliminating gluten from your diet might make the results of blood tests appear normal.
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Who should get screened?

Children older than 3 and adults experiencing symptoms of celiac disease should be tested
First-degree relatives of people with celiac disease – parents, siblings and children have a 1 in 10 risk compared to 1 in 100 in the general population
Any individual with an associated autoimmune disorder or other condition, especially type 1 diabetes mellitus, autoimmune thyroid disease, autoimmune liver disease, Down syndrome, Turner syndrome, Williams syndrome, and selective immunoglobulin A (IgA) deficiency

Gene List

HLA-DQ2
HLA-DQ8

Health Tips & Info

Additionally, children’s reference ranges are designed to provide more accurate pediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes.
For most children and adults, the best way to test for celiac disease is with the Tissue Transglutaminase IgA antibody (tTG-IgA), plus an IgA antibody in order to ensure that the patient generates enough of this antibody to render the celiac disease test accurate.

For young children (around age 2 years or below), Deamidated Gliadin IgA and IgG antibodies should also be included. All celiac disease blood tests require that you be on a gluten-containing diet to be accurate. The tTG-IgA test will be positive in about 93% of patients with celiac disease who are on a gluten-containing diet. This refers to the test’s sensitivity, which measures how correctly it identifies those with the disease. The same test will come back negative in about 96% of healthy people without celiac disease. This is the test’s specificity.
he EMA test has a specificity of almost 100%, making it the most specific test for celiac disease, although it is not as sensitive as the tTG-IgA test. About 5-10% of people with celiac disease do not have a positive EMA test. It is also very expensive in comparison to the tTG-IgA and requires the use of primate esophagus or human umbilical cord. It is usually reserved for difficult to diagnose patients.

Total serum IgA: This test is used to check for IgA deficiency, a condition associated with celiac disease that can cause a false negative tTG-IgA or EMA result. If you are IgA deficient, your doctor can order a DGP or tTG-IgG test.

Who should have Celiac HLA testing?

Those on a gluten-free diet – celiac antibody blood testing is not accurate
when diagnosis of celiac disease is not clear
ambiguous antibody testing results (especially in children under the age of 3)
ambiguous antibody testing results (especially in children under the age of 3)
discrepancy between antibody and biopsy findings
family members of people with celiac disease to evaluate risk
a negative result assures a 99% probability that the family member will NOT develop celiac disease
£120
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